Small COPII coat GTPase SAR1B (SAR1B)
Homo sapiens — UniProt Q9Y6B6
Data last refreshed: (UniProt release unknown)
Key facts
Small COPII coat GTPase SAR1B (SAR1B) is a protein from Homo sapiens identified by UniProt accession Q9Y6B6, 198 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.
- UniProt accession: Q9Y6B6; gene symbol SAR1B.
- Organism: Homo sapiens.
- Length: 198 amino acids.
- Top disease associations (Open Targets): chylomicron retention disease, genetic disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small COPII coat GTPase SAR1B |
|---|---|
| UniProt accession | Q9Y6B6 |
| Gene | SAR1B |
| Organism | Homo sapiens |
| Length | 198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (115)
Diseases linked to this target (Open Targets).
- chylomicron retention disease · score 0.77
- genetic disorder · score 0.46
- neurodegenerative disease · score 0.33
- age at menarche · score 0.14
- puberty onset measurement · score 0.12
- hereditary chronic pancreatitis · score 0.12
- age at voice drop · score 0.11
- age at first facial hair · score 0.11
- appendicular lean mass · score 0.10
- vital capacity · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6B6-F1 | alphafold | PREDICTED | 86.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6B6.
Amino-acid sequence (198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAR1B?
The strongest Open Targets associations for SAR1B are chylomicron retention disease, genetic disorder, neurodegenerative disease, age at menarche and puberty onset measurement.
How long is the SAR1B protein?
The Homo sapiens SAR1B protein (UniProt Q9Y6B6) is 198 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6B6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6B6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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