AP-4 complex subunit beta-1 (AP4B1)
Homo sapiens — UniProt Q9Y6B7
Data last refreshed: (UniProt release unknown)
Key facts
AP-4 complex subunit beta-1 (AP4B1) is a protein from Homo sapiens identified by UniProt accession Q9Y6B7, 739 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9Y6B7; gene symbol AP4B1.
- Organism: Homo sapiens.
- Length: 739 amino acids.
- Top disease associations (Open Targets): Severe intellectual disability and progressive spastic paraplegia, Spastic paraplegia and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | AP-4 complex subunit beta-1 |
|---|---|
| UniProt accession | Q9Y6B7 |
| Gene | AP4B1 |
| Organism | Homo sapiens |
| Length | 739 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- Severe intellectual disability and progressive spastic paraplegia · score 0.79
- Spastic paraplegia · score 0.71
- genetic disorder · score 0.52
- AP-4 deficiency syndrome · score 0.37
- hereditary spastic paraplegia · score 0.34
- Abnormality of the nervous system · score 0.34
- Abnormal brain morphology · score 0.33
- breast carcinoma · score 0.21
- Hoyeraal-Hreidarsson syndrome · score 0.17
- systemic lupus erythematosus · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6B7-F1 | alphafold | PREDICTED | 86.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6B7.
Amino-acid sequence (739 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AP4B1?
The strongest Open Targets associations for AP4B1 are Severe intellectual disability and progressive spastic paraplegia, Spastic paraplegia, genetic disorder, AP-4 deficiency syndrome and hereditary spastic paraplegia.
How long is the AP4B1 protein?
The Homo sapiens AP4B1 protein (UniProt Q9Y6B7) is 739 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6B7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6B7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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