Protein patched homolog 2 (PTCH2)
Homo sapiens — UniProt Q9Y6C5
Data last refreshed: (UniProt release unknown)
Key facts
Protein patched homolog 2 (PTCH2) is a protein from Homo sapiens identified by UniProt accession Q9Y6C5, 1203 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.
- UniProt accession: Q9Y6C5; gene symbol PTCH2.
- Organism: Homo sapiens.
- Length: 1203 amino acids.
- Top disease associations (Open Targets): basal cell carcinoma, nevoid basal cell carcinoma syndrome and medulloblastoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein patched homolog 2 |
|---|---|
| UniProt accession | Q9Y6C5 |
| Gene | PTCH2 |
| Organism | Homo sapiens |
| Length | 1203 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (298)
Diseases linked to this target (Open Targets).
- basal cell carcinoma · score 0.61
- nevoid basal cell carcinoma syndrome · score 0.54
- medulloblastoma · score 0.48
- neurodegenerative disease · score 0.43
- lateral facial cleft · score 0.37
- hereditary breast carcinoma · score 0.27
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- breast carcinoma · score 0.15
- platelet component distribution width · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6C5-F1 | alphafold | PREDICTED | 78.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6C5.
Amino-acid sequence (1203 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTCH2?
The strongest Open Targets associations for PTCH2 are basal cell carcinoma, nevoid basal cell carcinoma syndrome, medulloblastoma, neurodegenerative disease and lateral facial cleft.
How long is the PTCH2 protein?
The Homo sapiens PTCH2 protein (UniProt Q9Y6C5) is 1203 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6C5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6C5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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