Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2)
Homo sapiens — UniProt Q9Y6D5
Data last refreshed: (UniProt release unknown)
Key facts
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) is a protein from Homo sapiens identified by UniProt accession Q9Y6D5, 1785 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.
- UniProt accession: Q9Y6D5; gene symbol ARFGEF2.
- Organism: Homo sapiens.
- Length: 1785 amino acids.
- Top disease associations (Open Targets): nodular neuronal heterotopia, periventricular nodular heterotopia and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 |
|---|---|
| UniProt accession | Q9Y6D5 |
| Gene | ARFGEF2 |
| Organism | Homo sapiens |
| Length | 1785 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (104)
Diseases linked to this target (Open Targets).
- nodular neuronal heterotopia · score 0.62
- periventricular nodular heterotopia · score 0.46
- genetic disorder · score 0.41
- sex hormone-binding globulin measurement · score 0.31
- Global developmental delay · score 0.29
- neutrophil count · score 0.27
- Seizure · score 0.26
- Hydrocephalus · score 0.26
- glioblastoma multiforme · score 0.25
- lung adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6D5-F1 | alphafold | PREDICTED | 76.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6D5.
Amino-acid sequence (1785 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARFGEF2?
The strongest Open Targets associations for ARFGEF2 are nodular neuronal heterotopia, periventricular nodular heterotopia, genetic disorder, sex hormone-binding globulin measurement and Global developmental delay.
How long is the ARFGEF2 protein?
The Homo sapiens ARFGEF2 protein (UniProt Q9Y6D5) is 1785 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6D5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6D5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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