Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)
Homo sapiens — UniProt Q9Y6D9
Data last refreshed: (UniProt release unknown)
Key facts
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) is a protein from Homo sapiens identified by UniProt accession Q9Y6D9, 718 residues long. MolForge cross-references it against 0 known binders and 205 disease associations.
- UniProt accession: Q9Y6D9; gene symbol MAD1L1.
- Organism: Homo sapiens.
- Length: 718 amino acids.
- Top disease associations (Open Targets): mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition, neurodegenerative disease and mosaic variegated aneuploidy syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitotic spindle assembly checkpoint protein MAD1 |
|---|---|
| UniProt accession | Q9Y6D9 |
| Gene | MAD1L1 |
| Organism | Homo sapiens |
| Length | 718 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (205)
Diseases linked to this target (Open Targets).
- mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition · score 0.52
- neurodegenerative disease · score 0.45
- mosaic variegated aneuploidy syndrome · score 0.43
- prostate carcinoma · score 0.39
- self reported educational attainment · score 0.35
- schizophrenia · score 0.33
- mathematical ability · score 0.33
- body mass index · score 0.30
- sex hormone-binding globulin measurement · score 0.30
- vital capacity · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6D9-F1 | alphafold | PREDICTED | 81.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6D9.
Amino-acid sequence (718 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAD1L1?
The strongest Open Targets associations for MAD1L1 are mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition, neurodegenerative disease, mosaic variegated aneuploidy syndrome, prostate carcinoma and self reported educational attainment.
How long is the MAD1L1 protein?
The Homo sapiens MAD1L1 protein (UniProt Q9Y6D9) is 718 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6D9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6D9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.