NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4)
Homo sapiens — UniProt Q9Y6E7
Data last refreshed: (UniProt release unknown)
Key facts
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4) is a protein from Homo sapiens identified by UniProt accession Q9Y6E7, 314 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.
- UniProt accession: Q9Y6E7; gene symbol SIRT4.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, appendicular lean mass and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
|---|---|
| UniProt accession | Q9Y6E7 |
| Gene | SIRT4 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (153)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.27
- appendicular lean mass · score 0.23
- systolic blood pressure · score 0.23
- lymphocyte count · score 0.22
- C-reactive protein measurement · score 0.19
- mean corpuscular volume · score 0.18
- reticulocyte count · score 0.17
- brain measurement · score 0.11
- rheumatoid arthritis · score 0.11
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6E7-F1 | alphafold | PREDICTED | 90.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6E7.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIRT4?
The strongest Open Targets associations for SIRT4 are diastolic blood pressure, appendicular lean mass, systolic blood pressure, lymphocyte count and C-reactive protein measurement.
How long is the SIRT4 protein?
The Homo sapiens SIRT4 protein (UniProt Q9Y6E7) is 314 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6E7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6E7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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