Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)
Homo sapiens — UniProt Q9Y6F6
Data last refreshed: (UniProt release unknown)
Key facts
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) is a protein from Homo sapiens identified by UniProt accession Q9Y6F6, 904 residues long. MolForge cross-references it against 0 known binders and 223 disease associations.
- UniProt accession: Q9Y6F6; gene symbol IRAG1.
- Organism: Homo sapiens.
- Length: 904 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, mean platelet volume and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inositol 1,4,5-triphosphate receptor associated 1 |
|---|---|
| UniProt accession | Q9Y6F6 |
| Gene | IRAG1 |
| Organism | Homo sapiens |
| Length | 904 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (223)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.44
- mean platelet volume · score 0.43
- diastolic blood pressure · score 0.43
- migraine disorder · score 0.42
- platelet count · score 0.42
- erythrocyte count · score 0.40
- brain volume measurement · score 0.38
- asthma · score 0.37
- hemoglobin measurement · score 0.37
- migraine with aura · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6F6-F1 | alphafold | PREDICTED | 55.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6F6.
Amino-acid sequence (904 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IRAG1?
The strongest Open Targets associations for IRAG1 are systolic blood pressure, mean platelet volume, diastolic blood pressure, migraine disorder and platelet count.
How long is the IRAG1 protein?
The Homo sapiens IRAG1 protein (UniProt Q9Y6F6) is 904 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6F6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6F6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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