Potassium voltage-gated channel subfamily E member 3 (KCNE3)
Homo sapiens — UniProt Q9Y6H6
Data last refreshed: (UniProt release unknown)
Key facts
Potassium voltage-gated channel subfamily E member 3 (KCNE3) is a protein from Homo sapiens identified by UniProt accession Q9Y6H6, 103 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.
- UniProt accession: Q9Y6H6; gene symbol KCNE3.
- Organism: Homo sapiens.
- Length: 103 amino acids.
- Top disease associations (Open Targets): Brugada syndrome, Abnormality of the cardiovascular system and Prolonged QT interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium voltage-gated channel subfamily E member 3 |
|---|---|
| UniProt accession | Q9Y6H6 |
| Gene | KCNE3 |
| Organism | Homo sapiens |
| Length | 103 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (163)
Diseases linked to this target (Open Targets).
- Brugada syndrome · score 0.23
- Abnormality of the cardiovascular system · score 0.19
- Prolonged QT interval · score 0.17
- Osteopetrosis with renal tubular acidosis · score 0.12
- Syncope · score 0.12
- ventricular fibrillation · score 0.12
- cutaneous melanoma · score 0.10
- hemoglobin measurement · score 0.10
- glioblastoma multiforme · score 0.09
- osteoarthritis, knee · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6H6-F1 | alphafold | PREDICTED | 71.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6H6.
Amino-acid sequence (103 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNE3?
The strongest Open Targets associations for KCNE3 are Brugada syndrome, Abnormality of the cardiovascular system, Prolonged QT interval, Osteopetrosis with renal tubular acidosis and Syncope.
How long is the KCNE3 protein?
The Homo sapiens KCNE3 protein (UniProt Q9Y6H6) is 103 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6H6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6H6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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