Gap junction alpha-3 protein (GJA3)
Homo sapiens — UniProt Q9Y6H8
Data last refreshed: (UniProt release unknown)
Key facts
Gap junction alpha-3 protein (GJA3) is a protein from Homo sapiens identified by UniProt accession Q9Y6H8, 435 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.
- UniProt accession: Q9Y6H8; gene symbol GJA3.
- Organism: Homo sapiens.
- Length: 435 amino acids.
- Top disease associations (Open Targets): Posterior polar cataract, early-onset non-syndromic cataract and Developmental cataract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gap junction alpha-3 protein |
|---|---|
| UniProt accession | Q9Y6H8 |
| Gene | GJA3 |
| Organism | Homo sapiens |
| Length | 435 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (174)
Diseases linked to this target (Open Targets).
- Posterior polar cataract · score 0.83
- early-onset non-syndromic cataract · score 0.66
- Developmental cataract · score 0.49
- pulverulent cataract · score 0.39
- early-onset posterior polar cataract · score 0.37
- early-onset nuclear cataract · score 0.37
- congenital cataracts-facial dysmorphism-neuropathy syndrome · score 0.34
- Congenital cataracts - facial dysmorphism - neuropathy · score 0.34
- Mutism · score 0.25
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6H8-F1 | alphafold | PREDICTED | 67.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6H8.
Amino-acid sequence (435 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GJA3?
The strongest Open Targets associations for GJA3 are Posterior polar cataract, early-onset non-syndromic cataract, Developmental cataract, pulverulent cataract and early-onset posterior polar cataract.
How long is the GJA3 protein?
The Homo sapiens GJA3 protein (UniProt Q9Y6H8) is 435 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6H8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6H8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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