Ubiquitin carboxyl-terminal hydrolase 3 (USP3)
Homo sapiens — UniProt Q9Y6I4
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 3 (USP3) is a protein from Homo sapiens identified by UniProt accession Q9Y6I4, 520 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.
- UniProt accession: Q9Y6I4; gene symbol USP3.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, reticulocyte count and sex hormone-binding globulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 3 |
|---|---|
| UniProt accession | Q9Y6I4 |
| Gene | USP3 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (125)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.35
- reticulocyte count · score 0.35
- sex hormone-binding globulin measurement · score 0.32
- serum alanine aminotransferase measurement · score 0.31
- heel bone mineral density · score 0.30
- vitamin D measurement · score 0.30
- testosterone measurement · score 0.29
- triglyceride measurement · score 0.28
- FEV/FVC ratio · score 0.27
- body mass index · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6I4-F1 | alphafold | PREDICTED | 78.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6I4.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP3?
The strongest Open Targets associations for USP3 are low density lipoprotein cholesterol measurement, reticulocyte count, sex hormone-binding globulin measurement, serum alanine aminotransferase measurement and heel bone mineral density.
How long is the USP3 protein?
The Homo sapiens USP3 protein (UniProt Q9Y6I4) is 520 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6I4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6I4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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