Potassium voltage-gated channel subfamily E member 2 (KCNE2)
Homo sapiens — UniProt Q9Y6J6
Data last refreshed: (UniProt release unknown)
Key facts
Potassium voltage-gated channel subfamily E member 2 (KCNE2) is a protein from Homo sapiens identified by UniProt accession Q9Y6J6, 123 residues long. MolForge cross-references it against 0 known binders and 266 disease associations.
- UniProt accession: Q9Y6J6; gene symbol KCNE2.
- Organism: Homo sapiens.
- Length: 123 amino acids.
- Top disease associations (Open Targets): Romano-Ward syndrome, familial atrial fibrillation and familial long QT syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium voltage-gated channel subfamily E member 2 |
|---|---|
| UniProt accession | Q9Y6J6 |
| Gene | KCNE2 |
| Organism | Homo sapiens |
| Length | 123 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (266)
Diseases linked to this target (Open Targets).
- Romano-Ward syndrome · score 0.75
- familial atrial fibrillation · score 0.48
- familial long QT syndrome · score 0.41
- coronary artery disease · score 0.40
- myocardial infarction · score 0.39
- pulse pressure measurement · score 0.36
- BMI-adjusted waist-hip ratio · score 0.36
- FEV/FVC ratio · score 0.35
- angina pectoris · score 0.34
- waist-hip ratio · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6J6-F1 | alphafold | PREDICTED | 78.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6J6.
Amino-acid sequence (123 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNE2?
The strongest Open Targets associations for KCNE2 are Romano-Ward syndrome, familial atrial fibrillation, familial long QT syndrome, coronary artery disease and myocardial infarction.
How long is the KCNE2 protein?
The Homo sapiens KCNE2 protein (UniProt Q9Y6J6) is 123 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6J6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6J6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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