2'-5'-oligoadenylate synthase 3 (OAS3)
Homo sapiens — UniProt Q9Y6K5
Data last refreshed: (UniProt release unknown)
Key facts
2'-5'-oligoadenylate synthase 3 (OAS3) is a protein from Homo sapiens identified by UniProt accession Q9Y6K5, 1087 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.
- UniProt accession: Q9Y6K5; gene symbol OAS3.
- Organism: Homo sapiens.
- Length: 1087 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, COVID-19 and alcohol drinking.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2'-5'-oligoadenylate synthase 3 |
|---|---|
| UniProt accession | Q9Y6K5 |
| Gene | OAS3 |
| Organism | Homo sapiens |
| Length | 1087 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (135)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- COVID-19 · score 0.30
- alcohol drinking · score 0.27
- high density lipoprotein cholesterol measurement · score 0.24
- type 2 diabetes mellitus · score 0.21
- hypertension · score 0.21
- alcohol consumption measurement · score 0.20
- thyroid gland adenocarcinoma · score 0.18
- chronic lymphocytic leukemia · score 0.15
- systemic lupus erythematosus · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6K5-F1 | alphafold | PREDICTED | 86.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6K5.
Amino-acid sequence (1087 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OAS3?
The strongest Open Targets associations for OAS3 are neurodegenerative disease, COVID-19, alcohol drinking, high density lipoprotein cholesterol measurement and type 2 diabetes mellitus.
How long is the OAS3 protein?
The Homo sapiens OAS3 protein (UniProt Q9Y6K5) is 1087 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6K5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6K5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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