NF-kappa-B essential modulator (IKBKG)
Homo sapiens — UniProt Q9Y6K9
Data last refreshed: (UniProt release unknown)
Key facts
NF-kappa-B essential modulator (IKBKG) is a protein from Homo sapiens identified by UniProt accession Q9Y6K9, 419 residues long. MolForge cross-references it against 0 known binders and 519 disease associations.
- UniProt accession: Q9Y6K9; gene symbol IKBKG.
- Organism: Homo sapiens.
- Length: 419 amino acids.
- Top disease associations (Open Targets): incontinentia pigmenti, ectodermal dysplasia and immunodeficiency 1 and immunodeficiency 33.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NF-kappa-B essential modulator |
|---|---|
| UniProt accession | Q9Y6K9 |
| Gene | IKBKG |
| Organism | Homo sapiens |
| Length | 419 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (519)
Diseases linked to this target (Open Targets).
- incontinentia pigmenti · score 0.83
- ectodermal dysplasia and immunodeficiency 1 · score 0.81
- immunodeficiency 33 · score 0.80
- Hypohidrotic ectodermal dysplasia with immunodeficiency · score 0.77
- Anhidrotic ectodermal dysplasia - immunodeficiency - osteopetrosis - lymphedema · score 0.67
- anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome · score 0.61
- autoinflammatory disease, X-linked · score 0.58
- anemia, nonspherocytic hemolytic, due to G6PD deficiency · score 0.53
- COVID-19 · score 0.47
- genetic disorder · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6K9-F1 | alphafold | PREDICTED | 81.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6K9.
Amino-acid sequence (419 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IKBKG?
The strongest Open Targets associations for IKBKG are incontinentia pigmenti, ectodermal dysplasia and immunodeficiency 1, immunodeficiency 33, Hypohidrotic ectodermal dysplasia with immunodeficiency and Anhidrotic ectodermal dysplasia - immunodeficiency - osteopetrosis - lymphedema.
How long is the IKBKG protein?
The Homo sapiens IKBKG protein (UniProt Q9Y6K9) is 419 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6K9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6K9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.