Tolloid-like protein 2 (TLL2)
Homo sapiens — UniProt Q9Y6L7
Data last refreshed: (UniProt release unknown)
Key facts
Tolloid-like protein 2 (TLL2) is a protein from Homo sapiens identified by UniProt accession Q9Y6L7, 1015 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9Y6L7; gene symbol TLL2.
- Organism: Homo sapiens.
- Length: 1015 amino acids.
- Top disease associations (Open Targets): neuroinflammatory disorder, adolescent idiopathic scoliosis and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tolloid-like protein 2 |
|---|---|
| UniProt accession | Q9Y6L7 |
| Gene | TLL2 |
| Organism | Homo sapiens |
| Length | 1015 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.33
- adolescent idiopathic scoliosis · score 0.32
- breast adenocarcinoma · score 0.25
- gut microbiome measurement · score 0.25
- cutaneous melanoma · score 0.23
- spinal muscular atrophy · score 0.15
- Proximal amyotrophy · score 0.15
- Hand tremor · score 0.15
- EMG: neuropathic changes · score 0.15
- muscular atrophy · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6L7-F1 | alphafold | PREDICTED | 81.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6L7.
Amino-acid sequence (1015 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TLL2?
The strongest Open Targets associations for TLL2 are neuroinflammatory disorder, adolescent idiopathic scoliosis, breast adenocarcinoma, gut microbiome measurement and cutaneous melanoma.
How long is the TLL2 protein?
The Homo sapiens TLL2 protein (UniProt Q9Y6L7) is 1015 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6L7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6L7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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