Testisin (PRSS21)
Homo sapiens — UniProt Q9Y6M0
Data last refreshed: (UniProt release unknown)
Key facts
Testisin (PRSS21) is a protein from Homo sapiens identified by UniProt accession Q9Y6M0, 314 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.
- UniProt accession: Q9Y6M0; gene symbol PRSS21.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Testisin |
|---|---|
| UniProt accession | Q9Y6M0 |
| Gene | PRSS21 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (130)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- neoplasm · score 0.09
- partial chromosome Y deletion · score 0.07
- blood protein measurement · score 0.07
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 56 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
- spermatogenic failure 40 · score 0.07
- spermatogenic failure 72 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6M0-F1 | alphafold | PREDICTED | 84.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6M0.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRSS21?
The strongest Open Targets associations for PRSS21 are azoospermia, male infertility with teratozoospermia due to single gene mutation, neoplasm, partial chromosome Y deletion and blood protein measurement.
How long is the PRSS21 protein?
The Homo sapiens PRSS21 protein (UniProt Q9Y6M0) is 314 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6M0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6M0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.