Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
Homo sapiens — UniProt Q9Y6M1
Data last refreshed: (UniProt release unknown)
Key facts
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a protein from Homo sapiens identified by UniProt accession Q9Y6M1, 599 residues long. MolForge cross-references it against 0 known binders and 332 disease associations.
- UniProt accession: Q9Y6M1; gene symbol IGF2BP2.
- Organism: Homo sapiens.
- Length: 599 amino acids.
- Top disease associations (Open Targets): body height, lean body mass and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Insulin-like growth factor 2 mRNA-binding protein 2 |
|---|---|
| UniProt accession | Q9Y6M1 |
| Gene | IGF2BP2 |
| Organism | Homo sapiens |
| Length | 599 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (332)
Diseases linked to this target (Open Targets).
- body height · score 0.69
- lean body mass · score 0.57
- type 2 diabetes mellitus · score 0.52
- forced expiratory volume · score 0.51
- diabetes mellitus · score 0.48
- mean corpuscular volume · score 0.47
- platelet count · score 0.46
- body weight · score 0.45
- appendicular lean mass · score 0.43
- BMI-adjusted waist-hip ratio · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6M1-F1 | alphafold | PREDICTED | 77.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6M1.
Amino-acid sequence (599 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IGF2BP2?
The strongest Open Targets associations for IGF2BP2 are body height, lean body mass, type 2 diabetes mellitus, forced expiratory volume and diabetes mellitus.
How long is the IGF2BP2 protein?
The Homo sapiens IGF2BP2 protein (UniProt Q9Y6M1) is 599 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6M1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6M1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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