Harmonin (USH1C)
Homo sapiens — UniProt Q9Y6N9
Data last refreshed: (UniProt release unknown)
Key facts
Harmonin (USH1C) is a protein from Homo sapiens identified by UniProt accession Q9Y6N9, 552 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.
- UniProt accession: Q9Y6N9; gene symbol USH1C.
- Organism: Homo sapiens.
- Length: 552 amino acids.
- Top disease associations (Open Targets): Usher syndrome type 1C, autosomal recessive nonsyndromic hearing loss 18A and Usher syndrome type 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Harmonin |
|---|---|
| UniProt accession | Q9Y6N9 |
| Gene | USH1C |
| Organism | Homo sapiens |
| Length | 552 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (166)
Diseases linked to this target (Open Targets).
- Usher syndrome type 1C · score 0.75
- autosomal recessive nonsyndromic hearing loss 18A · score 0.73
- Usher syndrome type 1 · score 0.67
- deafness · score 0.59
- Usher syndrome · score 0.51
- Usher syndrome type 2 · score 0.46
- hearing loss, autosomal recessive · score 0.45
- Retinal dystrophy · score 0.44
- retinitis pigmentosa · score 0.43
- Rare genetic deafness · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6N9-F1 | alphafold | PREDICTED | 79.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6N9.
Amino-acid sequence (552 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USH1C?
The strongest Open Targets associations for USH1C are Usher syndrome type 1C, autosomal recessive nonsyndromic hearing loss 18A, Usher syndrome type 1, deafness and Usher syndrome.
How long is the USH1C protein?
The Homo sapiens USH1C protein (UniProt Q9Y6N9) is 552 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6N9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6N9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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