Sestrin-1 (SESN1)
Homo sapiens — UniProt Q9Y6P5
Data last refreshed: (UniProt release unknown)
Key facts
Sestrin-1 (SESN1) is a protein from Homo sapiens identified by UniProt accession Q9Y6P5, 492 residues long. MolForge cross-references it against 0 known binders and 284 disease associations.
- UniProt accession: Q9Y6P5; gene symbol SESN1.
- Organism: Homo sapiens.
- Length: 492 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, eosinophil count and birth weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sestrin-1 |
|---|---|
| UniProt accession | Q9Y6P5 |
| Gene | SESN1 |
| Organism | Homo sapiens |
| Length | 492 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (284)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.49
- eosinophil count · score 0.45
- birth weight · score 0.45
- mean corpuscular hemoglobin concentration · score 0.43
- mean reticulocyte volume · score 0.41
- mean corpuscular hemoglobin · score 0.41
- hypothyroidism · score 0.38
- prostate carcinoma · score 0.37
- erythrocyte count · score 0.36
- FEV/FVC ratio · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6P5-F1 | alphafold | PREDICTED | 83.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6P5.
Amino-acid sequence (492 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SESN1?
The strongest Open Targets associations for SESN1 are mean corpuscular volume, eosinophil count, birth weight, mean corpuscular hemoglobin concentration and mean reticulocyte volume.
How long is the SESN1 protein?
The Homo sapiens SESN1 protein (UniProt Q9Y6P5) is 492 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6P5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6P5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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