AP-1 complex subunit mu-2 (AP1M2)
Homo sapiens — UniProt Q9Y6Q5
Data last refreshed: (UniProt release unknown)
Key facts
AP-1 complex subunit mu-2 (AP1M2) is a protein from Homo sapiens identified by UniProt accession Q9Y6Q5, 423 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: Q9Y6Q5; gene symbol AP1M2.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): HIV infection, neurodegenerative disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | AP-1 complex subunit mu-2 |
|---|---|
| UniProt accession | Q9Y6Q5 |
| Gene | AP1M2 |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.50
- neurodegenerative disease · score 0.33
- Alzheimer disease · score 0.27
- lysosomal storage disease · score 0.27
- Parkinson disease · score 0.27
- multiple sclerosis · score 0.27
- Red cell distribution width · score 0.25
- basophil count · score 0.22
- low density lipoprotein cholesterol measurement · score 0.17
- total cholesterol measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6Q5-F1 | alphafold | PREDICTED | 92.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6Q5.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AP1M2?
The strongest Open Targets associations for AP1M2 are HIV infection, neurodegenerative disease, Alzheimer disease, lysosomal storage disease and Parkinson disease.
How long is the AP1M2 protein?
The Homo sapiens AP1M2 protein (UniProt Q9Y6Q5) is 423 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6Q5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6Q5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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