Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)
Homo sapiens — UniProt Q9Y6Q6
Data last refreshed: (UniProt release unknown)
Key facts
Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A) is a protein from Homo sapiens identified by UniProt accession Q9Y6Q6, 616 residues long. MolForge cross-references it against 0 known binders and 625 disease associations.
- UniProt accession: Q9Y6Q6; gene symbol TNFRSF11A.
- Organism: Homo sapiens.
- Length: 616 amino acids.
- Top disease associations (Open Targets): autosomal recessive osteopetrosis 7, Osteopetrosis - hypogammaglobulinemia and osteitis deformans.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 11A |
|---|---|
| UniProt accession | Q9Y6Q6 |
| Gene | TNFRSF11A |
| Organism | Homo sapiens |
| Length | 616 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (625)
Diseases linked to this target (Open Targets).
- autosomal recessive osteopetrosis 7 · score 0.73
- Osteopetrosis - hypogammaglobulinemia · score 0.69
- osteitis deformans · score 0.68
- familial expansile osteolysis · score 0.66
- heel bone mineral density · score 0.50
- alkaline phosphatase measurement · score 0.50
- bone density · score 0.50
- asthma · score 0.50
- osteopetrosis · score 0.46
- Eczematoid dermatitis · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6Q6-F1 | alphafold | PREDICTED | 58.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6Q6.
Amino-acid sequence (616 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TNFRSF11A?
The strongest Open Targets associations for TNFRSF11A are autosomal recessive osteopetrosis 7, Osteopetrosis - hypogammaglobulinemia, osteitis deformans, familial expansile osteolysis and heel bone mineral density.
How long is the TNFRSF11A protein?
The Homo sapiens TNFRSF11A protein (UniProt Q9Y6Q6) is 616 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6Q6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6Q6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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