Nuclear receptor coactivator 3 (NCOA3)
Homo sapiens — UniProt Q9Y6Q9
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear receptor coactivator 3 (NCOA3) is a protein from Homo sapiens identified by UniProt accession Q9Y6Q9, 1424 residues long. MolForge cross-references it against 0 known binders and 294 disease associations.
- UniProt accession: Q9Y6Q9; gene symbol NCOA3.
- Organism: Homo sapiens.
- Length: 1424 amino acids.
- Target class: Nuclear receptor.
- Top disease associations (Open Targets): platelet count, apolipoprotein A 1 measurement and Sensorineural hearing impairment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear receptor coactivator 3 |
|---|---|
| UniProt accession | Q9Y6Q9 |
| Gene | NCOA3 |
| Organism | Homo sapiens |
| Length | 1424 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Nuclear receptor (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (294)
Diseases linked to this target (Open Targets).
- platelet count · score 0.35
- apolipoprotein A 1 measurement · score 0.35
- Sensorineural hearing impairment · score 0.34
- high density lipoprotein cholesterol measurement · score 0.32
- osteoarthritis · score 0.29
- total blood protein measurement · score 0.27
- thyroid peroxidase antibody measurement · score 0.26
- breast adenocarcinoma · score 0.24
- endometrial cancer · score 0.23
- platelet crit · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6Q9-F1 | alphafold | PREDICTED | 48.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6Q9.
Amino-acid sequence (1424 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NCOA3?
The strongest Open Targets associations for NCOA3 are platelet count, apolipoprotein A 1 measurement, Sensorineural hearing impairment, high density lipoprotein cholesterol measurement and osteoarthritis.
How long is the NCOA3 protein?
The Homo sapiens NCOA3 protein (UniProt Q9Y6Q9) is 1424 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6Q9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6Q9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.