Numb-like protein (NUMBL)
Homo sapiens — UniProt Q9Y6R0
Data last refreshed: (UniProt release unknown)
Key facts
Numb-like protein (NUMBL) is a protein from Homo sapiens identified by UniProt accession Q9Y6R0, 609 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q9Y6R0; gene symbol NUMBL.
- Organism: Homo sapiens.
- Length: 609 amino acids.
- Top disease associations (Open Targets): nicotine metabolite ratio, hemoglobin measurement and brain volume measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Numb-like protein |
|---|---|
| UniProt accession | Q9Y6R0 |
| Gene | NUMBL |
| Organism | Homo sapiens |
| Length | 609 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- nicotine metabolite ratio · score 0.28
- hemoglobin measurement · score 0.22
- brain volume measurement · score 0.19
- red blood cell density measurement · score 0.17
- hematocrit · score 0.14
- serum urea measurement · score 0.10
- erythrocyte count · score 0.10
- neoplasm · score 0.10
- cancer · score 0.09
- Miyoshi myopathy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6R0-F1 | alphafold | PREDICTED | 61.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6R0.
Amino-acid sequence (609 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUMBL?
The strongest Open Targets associations for NUMBL are nicotine metabolite ratio, hemoglobin measurement, brain volume measurement, red blood cell density measurement and hematocrit.
How long is the NUMBL protein?
The Homo sapiens NUMBL protein (UniProt Q9Y6R0) is 609 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6R0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6R0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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