Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)
Homo sapiens — UniProt Q9Y6R1
Data last refreshed: (UniProt release unknown)
Key facts
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4) is a protein from Homo sapiens identified by UniProt accession Q9Y6R1, 1079 residues long. MolForge cross-references it against 0 known binders and 306 disease associations.
- UniProt accession: Q9Y6R1; gene symbol SLC4A4.
- Organism: Homo sapiens.
- Length: 1079 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): autosomal recessive proximal renal tubular acidosis, heel bone mineral density and IGF-1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Electrogenic sodium bicarbonate cotransporter 1 |
|---|---|
| UniProt accession | Q9Y6R1 |
| Gene | SLC4A4 |
| Organism | Homo sapiens |
| Length | 1079 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (306)
Diseases linked to this target (Open Targets).
- autosomal recessive proximal renal tubular acidosis · score 0.79
- heel bone mineral density · score 0.42
- IGF-1 measurement · score 0.38
- QT interval · score 0.31
- ulcerative colitis · score 0.31
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.11
- Genetic renal or urinary tract malformation · score 0.11
- Cystic Kidney Disease · score 0.10
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6R1-F1 | alphafold | PREDICTED | 70.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6R1.
Amino-acid sequence (1079 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC4A4?
The strongest Open Targets associations for SLC4A4 are autosomal recessive proximal renal tubular acidosis, heel bone mineral density, IGF-1 measurement, QT interval and ulcerative colitis.
How long is the SLC4A4 protein?
The Homo sapiens SLC4A4 protein (UniProt Q9Y6R1) is 1079 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6R1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6R1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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