Ribosomal protein S6 kinase-like 1 (RPS6KL1)
Homo sapiens — UniProt Q9Y6S9
Data last refreshed: (UniProt release unknown)
Key facts
Ribosomal protein S6 kinase-like 1 (RPS6KL1) is a protein from Homo sapiens identified by UniProt accession Q9Y6S9, 549 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q9Y6S9; gene symbol RPS6KL1.
- Organism: Homo sapiens.
- Length: 549 amino acids.
- Top disease associations (Open Targets): cortical surface area measurement, blood protein measurement and unipolar depression.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribosomal protein S6 kinase-like 1 |
|---|---|
| UniProt accession | Q9Y6S9 |
| Gene | RPS6KL1 |
| Organism | Homo sapiens |
| Length | 549 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.23
- blood protein measurement · score 0.19
- unipolar depression · score 0.13
- bipolar disorder · score 0.11
- Tourette syndrome · score 0.11
- autism spectrum disorder · score 0.11
- attention deficit hyperactivity disorder · score 0.11
- schizophrenia · score 0.11
- obsessive-compulsive disorder · score 0.11
- anorexia nervosa · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6S9-F1 | alphafold | PREDICTED | 67.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6S9.
Amino-acid sequence (549 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RPS6KL1?
The strongest Open Targets associations for RPS6KL1 are cortical surface area measurement, blood protein measurement, unipolar depression, bipolar disorder and Tourette syndrome.
How long is the RPS6KL1 protein?
The Homo sapiens RPS6KL1 protein (UniProt Q9Y6S9) is 549 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6S9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6S9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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