Diacylglycerol kinase beta (DGKB)
Homo sapiens — UniProt Q9Y6T7
Data last refreshed: (UniProt release unknown)
Key facts
Diacylglycerol kinase beta (DGKB) is a protein from Homo sapiens identified by UniProt accession Q9Y6T7, 804 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.
- UniProt accession: Q9Y6T7; gene symbol DGKB.
- Organism: Homo sapiens.
- Length: 804 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, fasting blood glucose measurement and diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Diacylglycerol kinase beta |
|---|---|
| UniProt accession | Q9Y6T7 |
| Gene | DGKB |
| Organism | Homo sapiens |
| Length | 804 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (183)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.52
- fasting blood glucose measurement · score 0.49
- diabetes mellitus · score 0.47
- glucose measurement · score 0.47
- FEV/FVC ratio · score 0.46
- mathematical ability · score 0.44
- body mass index · score 0.43
- HbA1c measurement · score 0.42
- Drugs used in diabetes use measurement · score 0.41
- HOMA-B · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6T7-F1 | alphafold | PREDICTED | 77.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6T7.
Amino-acid sequence (804 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DGKB?
The strongest Open Targets associations for DGKB are type 2 diabetes mellitus, fasting blood glucose measurement, diabetes mellitus, glucose measurement and FEV/FVC ratio.
How long is the DGKB protein?
The Homo sapiens DGKB protein (UniProt Q9Y6T7) is 804 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6T7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6T7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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