Probable ATP-dependent RNA helicase DDX49 (DDX49)
Homo sapiens — UniProt Q9Y6V7
Data last refreshed: (UniProt release unknown)
Key facts
Probable ATP-dependent RNA helicase DDX49 (DDX49) is a protein from Homo sapiens identified by UniProt accession Q9Y6V7, 483 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9Y6V7; gene symbol DDX49.
- Organism: Homo sapiens.
- Length: 483 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX49 |
|---|---|
| UniProt accession | Q9Y6V7 |
| Gene | DDX49 |
| Organism | Homo sapiens |
| Length | 483 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.17
- endometrial cancer · score 0.10
- hepatocellular carcinoma · score 0.07
- neoplasm · score 0.04
- lymph node metastatic carcinoma · score 0.04
- mean corpuscular hemoglobin · score 0.03
- cancer · score 0.03
- calf circumference measurement · score 0.02
- Kaposi's sarcoma · score 0.01
- glioblastoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6V7-F1 | alphafold | PREDICTED | 86.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6V7.
Amino-acid sequence (483 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX49?
The strongest Open Targets associations for DDX49 are neurodegenerative disease, endometrial cancer, hepatocellular carcinoma, neoplasm and lymph node metastatic carcinoma.
How long is the DDX49 protein?
The Homo sapiens DDX49 protein (UniProt Q9Y6V7) is 483 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6V7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6V7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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