Inducible T-cell costimulator (ICOS)
Homo sapiens — UniProt Q9Y6W8
Data last refreshed: (UniProt release unknown)
Key facts
Inducible T-cell costimulator (ICOS) is a protein from Homo sapiens identified by UniProt accession Q9Y6W8, 199 residues long. MolForge cross-references it against 0 known binders and 653 disease associations.
- UniProt accession: Q9Y6W8; gene symbol ICOS.
- Organism: Homo sapiens.
- Length: 199 amino acids.
- Top disease associations (Open Targets): common variable immunodeficiency, recurrent infections associated with rare immunoglobulin isotypes deficiency and combined immunodeficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inducible T-cell costimulator |
|---|---|
| UniProt accession | Q9Y6W8 |
| Gene | ICOS |
| Organism | Homo sapiens |
| Length | 199 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (653)
Diseases linked to this target (Open Targets).
- common variable immunodeficiency · score 0.75
- recurrent infections associated with rare immunoglobulin isotypes deficiency · score 0.47
- combined immunodeficiency · score 0.46
- Combined immunodeficiency · score 0.46
- cancer · score 0.40
- breast adenocarcinoma · score 0.29
- lung adenocarcinoma · score 0.28
- diastolic blood pressure · score 0.23
- head and neck squamous cell carcinoma · score 0.18
- genetic disorder · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6W8-F1 | alphafold | PREDICTED | 73.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6W8.
Amino-acid sequence (199 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ICOS?
The strongest Open Targets associations for ICOS are common variable immunodeficiency, recurrent infections associated with rare immunoglobulin isotypes deficiency, combined immunodeficiency, Combined immunodeficiency and cancer.
How long is the ICOS protein?
The Homo sapiens ICOS protein (UniProt Q9Y6W8) is 199 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6W8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6W8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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