E3 SUMO-protein ligase PIAS3 (PIAS3)
Homo sapiens — UniProt Q9Y6X2
Data last refreshed: (UniProt release unknown)
Key facts
E3 SUMO-protein ligase PIAS3 (PIAS3) is a protein from Homo sapiens identified by UniProt accession Q9Y6X2, 628 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q9Y6X2; gene symbol PIAS3.
- Organism: Homo sapiens.
- Length: 628 amino acids.
- Top disease associations (Open Targets): low grade glioma, glioblastoma multiforme and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 SUMO-protein ligase PIAS3 |
|---|---|
| UniProt accession | Q9Y6X2 |
| Gene | PIAS3 |
| Organism | Homo sapiens |
| Length | 628 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- low grade glioma · score 0.26
- glioblastoma multiforme · score 0.26
- endometrial cancer · score 0.25
- squamous cell lung carcinoma · score 0.19
- lung adenocarcinoma · score 0.19
- gastric adenocarcinoma · score 0.19
- head and neck squamous cell carcinoma · score 0.18
- granulocyte count · score 0.13
- prostate adenocarcinoma · score 0.10
- cutaneous melanoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6X2-F1 | alphafold | PREDICTED | 69.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6X2.
Amino-acid sequence (628 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIAS3?
The strongest Open Targets associations for PIAS3 are low grade glioma, glioblastoma multiforme, endometrial cancer, squamous cell lung carcinoma and lung adenocarcinoma.
How long is the PIAS3 protein?
The Homo sapiens PIAS3 protein (UniProt Q9Y6X2) is 628 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6X2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6X2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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