Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4)
Homo sapiens — UniProt Q9Y6X5
Data last refreshed: (UniProt release unknown)
Key facts
Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) is a protein from Homo sapiens identified by UniProt accession Q9Y6X5, 453 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q9Y6X5; gene symbol ENPP4.
- Organism: Homo sapiens.
- Length: 453 amino acids.
- Top disease associations (Open Targets): blood protein measurement, platelet component distribution width and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bis(5'-adenosyl)-triphosphatase ENPP4 |
|---|---|
| UniProt accession | Q9Y6X5 |
| Gene | ENPP4 |
| Organism | Homo sapiens |
| Length | 453 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.39
- platelet component distribution width · score 0.36
- mean corpuscular volume · score 0.35
- mean reticulocyte volume · score 0.30
- IGF-1 measurement · score 0.27
- hair shape measurement · score 0.10
- balding measurement · score 0.09
- blood phosphate measurement · score 0.05
- autosomal recessive hypophosphatemic rickets · score 0.05
- hypoparathyroidism, familial isolated, 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6X5-F1 | alphafold | PREDICTED | 92.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6X5.
Amino-acid sequence (453 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ENPP4?
The strongest Open Targets associations for ENPP4 are blood protein measurement, platelet component distribution width, mean corpuscular volume, mean reticulocyte volume and IGF-1 measurement.
How long is the ENPP4 protein?
The Homo sapiens ENPP4 protein (UniProt Q9Y6X5) is 453 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6X5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6X5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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