ATPase MORC2 (MORC2)
Homo sapiens — UniProt Q9Y6X9
Data last refreshed: (UniProt release unknown)
Key facts
ATPase MORC2 (MORC2) is a protein from Homo sapiens identified by UniProt accession Q9Y6X9, 1032 residues long. MolForge cross-references it against 0 known binders and 552 disease associations.
- UniProt accession: Q9Y6X9; gene symbol MORC2.
- Organism: Homo sapiens.
- Length: 1032 amino acids.
- Top disease associations (Open Targets): Charcot-Marie-Tooth disease axonal type 2Z, developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy and Global developmental delay.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATPase MORC2 |
|---|---|
| UniProt accession | Q9Y6X9 |
| Gene | MORC2 |
| Organism | Homo sapiens |
| Length | 1032 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (552)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease axonal type 2Z · score 0.82
- developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy · score 0.71
- Global developmental delay · score 0.57
- genetic disorder · score 0.49
- Growth delay · score 0.48
- Microcephaly · score 0.48
- microcephaly · score 0.48
- Intellectual disability · score 0.48
- Neurodevelopmental disorder · score 0.43
- neurodegenerative disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y6X9-F1 | alphafold | PREDICTED | 77.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y6X9.
Amino-acid sequence (1032 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MORC2?
The strongest Open Targets associations for MORC2 are Charcot-Marie-Tooth disease axonal type 2Z, developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy, Global developmental delay, genetic disorder and Growth delay.
How long is the MORC2 protein?
The Homo sapiens MORC2 protein (UniProt Q9Y6X9) is 1032 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y6X9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y6X9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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