Abarelix

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Abarelix is a drug catalogued in DrugCentral. It was first approved by the FDA in 2003. DrugCentral lists 1 molecular target, including GNRHR. Recorded indications include Ischemic priapism.

• Molecular targets: GNRHR (1 listed in DrugCentral).
• Indications: Ischemic priapism.
• ATC code: L02BX01 (Other hormone antagonists and related agents).
• Molecular formula: C72H95ClN14O14; molecular weight 1416.09 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Ischemic priapism

Contraindications (5)

• Breastfeeding (mother)
• Liver function tests abnormal
• Obesity
• Pregnancy, function
• Prolonged QT interval

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Gonadotropin-releasing hormone receptor	GNRHR	antagonist	Ki 9.49

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2003-11-25	FDA	—	SPECIALITY EUROPEAN

ATC classification

ATC code	Therapeutic hierarchy
L02BX01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ENDOCRINE THERAPY › HORMONE ANTAGONISTS AND RELATED AGENTS › Other hormone antagonists and related agents

Chemical structure

• Molecular formula: C₇₂H₉₅ClN₁₄O₁₄
• Molecular weight: 1416.09 g/mol
• CAS number: 183552-38-7
• InChIKey: AIWRTTMUVOZGPW-HSPKUQOVSA-N
• PubChem CID: 16131215

CC(C)C[C@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC1=CN=CC=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC=C2C=CC=CC2=C1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Abarelix used for?

DrugCentral lists the following indications for Abarelix: Ischemic priapism.

How does Abarelix work?

Its molecular targets in DrugCentral include GNRHR (antagonist).

When was Abarelix first approved?

Abarelix was first approved by the FDA in 2003.

What is the chemical formula of Abarelix?

Abarelix has the molecular formula C72H95ClN14O14 and a molecular weight of 1416.09 g/mol.

Sources

• DrugCentral drug card 35 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1252 — compound record and bioactivity
• PubChem CID 16131215 — chemical identifiers
• DrugBank DB00106 — drug record
• FDA UNII W486SJ5824 — substance identity
• DailyMed: FDA labels for Abarelix — current prescribing information (label search)
• UniProt P30968 (GNRHR) — target protein

How this page is built: methodology · editorial policy & corrections.