Gonadotropin-releasing hormone receptor (GNRHR)

About Gonadotropin-releasing hormone receptor

Gonadotropin-releasing hormone receptor (GNRHR) is a protein from Homo sapiens identified by UniProt accession P30968, 328 residues long. MolForge cross-references it against 0 known binders and 538 disease associations.

Target properties

Protein name	Gonadotropin-releasing hormone receptor
UniProt accession	P30968
Gene	GNRHR
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (15)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (538)

Diseases linked to this target (Open Targets).

hypogonadotropic hypogonadism · score 0.74
infertility · score 0.69
prostate cancer · score 0.60
prostate adenocarcinoma · score 0.60
prostate carcinoma · score 0.60
endometriosis · score 0.60
Central precocious puberty · score 0.59
uterine fibroid · score 0.59
polycystic ovary syndrome · score 0.59
neoplasm · score 0.58

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30968-F1	alphafold	PREDICTED	84.20	—

Amino-acid sequence (328 residues)

MANSASPEQN QNHCSAINNS IPLMQGNLPT LTLSGKIRVT VTFFLFLLSA TFNASFLLKL QKWTQKKEKG KKLSRMKLLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITRPLALK SNSKVGQSMV GLAWILSSVF AGPQLYIFRM IHLADSSGQT KVFSQCVTHC SFSQWWHQAF YNFFTFSCLF IIPLFIMLIC NAKIIFTLTR VLHQDPHELQ LNQSKNNIPR ARLKTLKMTV AFATSFTVCW TPYYVLGIWY WFDPEMLNRL SDPVNHFFFL FAFLNPCFDP LIYGYFSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards