Amcinonide

Corticosteroid — DERMATOLOGICALS

Key facts

Amcinonide is an ofp drug in the Corticosteroid class catalogued in DrugCentral. It was first approved by the FDA in 1979. Its mechanism of action is classified as Corticosteroid Hormone Receptor Agonists. DrugCentral lists 1 molecular target, including NR3C1. Recorded indications include Atopic dermatitis, Contact dermatitis, Discoid lupus erythematosus and Eruption of skin.

• Approval status: ofp (first approved 1979 by the FDA).
• Drug class: Corticosteroid.
• Mechanism of action: Corticosteroid Hormone Receptor Agonists.
• Molecular targets: NR3C1 (1 listed in DrugCentral).
• Indications: Atopic dermatitis, Contact dermatitis, Discoid lupus erythematosus, Eruption of skin and Granuloma annulare and others.
• ATC code: D07AC11 (Corticosteroids, potent (group III)).
• Molecular formula: C28H35FO7; molecular weight 502.58 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (12)

• Atopic dermatitis
• Contact dermatitis
• Discoid lupus erythematosus
• Eruption of skin
• Granuloma annulare
• Lichen simplex chronicus
• Plaque psoriasis
• Primary cutaneous T-cell lymphoma
• Pruritus ani
• Pruritus of genital organs
• Scalp psoriasis
• Seborrheic dermatitis

Contraindications (7)

• Atrophoderma
• Bilateral cataracts
• Diabetes mellitus type 1
• Diabetes mellitus type 2
• Glaucoma
• Peripheral vascular disease
• Tuberculosis of skin

Mechanism & targets

• Mechanism of action (MoA): Corticosteroid Hormone Receptor Agonists
• Established pharmacologic class: Corticosteroid

Molecular targets (1)

Target	Gene	Action	Activity
Glucocorticoid receptor	NR3C1	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1979-10-18	FDA	—	ASTELLAS

ATC classification

ATC code	Therapeutic hierarchy
D07AC11	DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, potent (group III)

Chemical structure

• Molecular formula: C₂₈H₃₅FO₇
• Molecular weight: 502.58 g/mol
• CAS number: —
• InChIKey: ILKJAFIWWBXGDU-MOGDOJJUSA-N
• PubChem CID: 443958

CC(=O)OCC(=O)[C@@]12OC3(CCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]21C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Amcinonide used for?

DrugCentral lists the following indications for Amcinonide: Atopic dermatitis, Contact dermatitis, Discoid lupus erythematosus, Eruption of skin, Granuloma annulare, Lichen simplex chronicus, Plaque psoriasis and Primary cutaneous T-cell lymphoma and others.

How does Amcinonide work?

Amcinonide is classified as Corticosteroid Hormone Receptor Agonists; its molecular targets in DrugCentral include NR3C1 (agonist).

When was Amcinonide first approved?

Amcinonide was first approved by the FDA in 1979.

What drug class does Amcinonide belong to?

Amcinonide is in the Corticosteroid class.

What is the chemical formula of Amcinonide?

Amcinonide has the molecular formula C28H35FO7 and a molecular weight of 502.58 g/mol.

Sources

• DrugCentral drug card 150 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200732 — compound record and bioactivity
• PubChem CID 443958 — chemical identifiers
• DrugBank DB00288 — drug record
• FDA UNII 423W026MA9 — substance identity
• DailyMed: FDA labels for Amcinonide — current prescribing information (label search)
• UniProt P04150 (NR3C1) — target protein

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