Fluocinonide

Corticosteroid — CARDIOVASCULAR SYSTEM

Key facts

Fluocinonide is an ofp drug in the Corticosteroid class catalogued in DrugCentral. It was first approved by the FDA in 1971. Its mechanism of action is classified as Corticosteroid Hormone Receptor Agonists. DrugCentral lists 2 molecular targets, including NR3C1 and PGR. Recorded indications include Atopic dermatitis, Contact dermatitis, Discoid lupus erythematosus and Eruption of skin.

• Approval status: ofp (first approved 1971 by the FDA).
• Drug class: Corticosteroid.
• Mechanism of action: Corticosteroid Hormone Receptor Agonists.
• Molecular targets: NR3C1 and PGR (2 listed in DrugCentral).
• Indications: Atopic dermatitis, Contact dermatitis, Discoid lupus erythematosus, Eruption of skin and Granuloma annulare and others.
• ATC code: C05AA11 (Corticosteroids).
• Molecular formula: C26H32F2O7; molecular weight 494.53 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (13)

• Atopic dermatitis
• Contact dermatitis
• Discoid lupus erythematosus
• Eruption of skin
• Granuloma annulare
• Inflammatory dermatosis
• Lichen simplex chronicus
• Plaque psoriasis
• Primary cutaneous T-cell lymphoma
• Pruritus ani
• Pruritus of genital organs
• Scalp psoriasis
• Seborrheic dermatitis

Contraindications (5)

• Diabetes mellitus
• Hypercortisolism
• Hyperglycemia
• Hypopituitarism
• Infection of skin AND/OR subcutaneous tissue

Mechanism & targets

• Mechanism of action (MoA): Corticosteroid Hormone Receptor Agonists
• Established pharmacologic class: Corticosteroid

Molecular targets (2)

Target	Gene	Action	Activity
Glucocorticoid receptor	NR3C1	agonist	Ki 8.62
Progesterone receptor	PGR	unknown	Ki 8.54

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1971-06-30	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
C05AA11	CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Corticosteroids
D07AC08	DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, potent (group III)
D07CC05	DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS › Corticosteroids, potent, combinations with antibiotics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Psoriasis	394.9
Dermatitis atopic	351.9
Drug ineffective	277.1
Skin exfoliation	227.8
Pruritus	188.8
Rash	143.8
Skin plaque	134.4
Dry skin	116.4
Product dose omission issue	108.9
Eczema	107.2
Papule	105.0
Sleep disorder due to a general medical condition	96.3

Chemical structure

• Molecular formula: C₂₆H₃₂F₂O₇
• Molecular weight: 494.53 g/mol
• CAS number: 356-12-7
• InChIKey: WJOHZNCJWYWUJD-IUGZLZTKSA-N
• PubChem CID: 91488

CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]1[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]21C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Fluocinonide used for?

DrugCentral lists the following indications for Fluocinonide: Atopic dermatitis, Contact dermatitis, Discoid lupus erythematosus, Eruption of skin, Granuloma annulare, Inflammatory dermatosis, Lichen simplex chronicus and Plaque psoriasis and others.

How does Fluocinonide work?

Fluocinonide is classified as Corticosteroid Hormone Receptor Agonists; its molecular targets in DrugCentral include NR3C1 (agonist) and PGR.

When was Fluocinonide first approved?

Fluocinonide was first approved by the FDA in 1971.

What drug class does Fluocinonide belong to?

Fluocinonide is in the Corticosteroid class.

What is the chemical formula of Fluocinonide?

Fluocinonide has the molecular formula C26H32F2O7 and a molecular weight of 494.53 g/mol.

Sources

• DrugCentral drug card 1205 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201390 — compound record and bioactivity
• PubChem CID 91488 — chemical identifiers
• DrugBank DB01047 — drug record
• FDA UNII 2W4A77YPAN — substance identity
• DailyMed: FDA labels for Fluocinonide — current prescribing information (label search)
• UniProt P04150 (NR3C1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.