Avobenzone

Drug profile

Key facts

Avobenzone is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1992. DrugCentral lists 1 molecular target, including TYR.

• Approval status: ofp (first approved 1992 by the FDA).
• Molecular targets: TYR (1 listed in DrugCentral).
• Molecular formula: C20H22O3; molecular weight 310.39 g/mol.

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Tyrosinase	TYR	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1992-12-07	FDA	—	BAYER HEALTHCARE LLC

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Macular degeneration	1441.8
Chronic sinusitis	549.2
Paraesthesia oral	503.7
Vaginal flatulence	472.3
Procedural pain	468.1
Female genital tract fistula	467.0
Radiculopathy	428.9
Proctitis	424.6
Vaginal discharge	420.6
Oral candidiasis	305.0
Frequent bowel movements	251.5
Colitis ulcerative	242.9

Chemical structure

• Molecular formula: C₂₀H₂₂O₃
• Molecular weight: 310.39 g/mol
• CAS number: —
• InChIKey: XNEFYCZVKIDDMS-UHFFFAOYSA-N
• PubChem CID: 51040

COC1=CC=C(C=C1)C(=O)CC(=O)C1=CC=C(C=C1)C(C)(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Avobenzone work?

Its molecular targets in DrugCentral include TYR (inhibitor).

When was Avobenzone first approved?

Avobenzone was first approved by the FDA in 1992.

What is the chemical formula of Avobenzone?

Avobenzone has the molecular formula C20H22O3 and a molecular weight of 310.39 g/mol.

Sources

• DrugCentral drug card 4242 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200522 — compound record and bioactivity
• PubChem CID 51040 — chemical identifiers
• DrugBank DB09495 — drug record
• FDA UNII G63QQF2NOX — substance identity
• DailyMed: FDA labels for Avobenzone — current prescribing information (label search)
• UniProt P14679 (TYR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.