About Tyrosinase
Tyrosinase (TYR) is a protein
from Homo sapiens identified by UniProt accession
P14679, 529 residues long.
MolForge cross-references it against 0 known binders and
739 disease associations.
Target properties
| Protein name | Tyrosinase |
|---|
| UniProt accession | P14679 |
|---|
| Gene | TYR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 529 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (739)
Diseases linked to this target (Open Targets).
- oculocutaneous albinism type 1A · score 0.85
- oculocutaneous albinism type 1B · score 0.81
- skin pigmentation · score 0.70
- skin pigmentation measurement · score 0.70
- oculocutaneous albinism type 1 · score 0.69
- hair colour measurement · score 0.68
- Ocular albinism with congenital sensorineural deafness · score 0.67
- oculocutaneous albinism type 6 · score 0.58
- oculocutaneous albinism · score 0.58
- cutaneous melanoma · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14679-F1 | alphafold | PREDICTED | 89.89 | — |
Amino-acid sequence (529 residues)
MLLAVLYCLL WSFQTSAGHF PRACVSSKNL MEKECCPPWS GDRSPCGQLS GRGSCQNILL SNAPLGPQFP FTGVDDRESW PSVFYNRTCQ CSGNFMGFNC GNCKFGFWGP NCTERRLLVR RNIFDLSAPE KDKFFAYLTL AKHTISSDYV IPIGTYGQMK NGSTPMFNDI NIYDLFVWMH YYVSMDALLG GSEIWRDIDF AHEAPAFLPW HRLFLLRWEQ EIQKLTGDEN FTIPYWDWRD AEKCDICTDE YMGGQHPTNP NLLSPASFFS SWQIVCSRLE EYNSHQSLCN GTPEGPLRRN PGNHDKSRTP RLPSSADVEF CLSLTQYESG SMDKAANFSF RNTLEGFASP LTGIADASQS SMHNALHIYM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW LRRHRPLQEV YPEANAPIGH NRESYMVPFI PLYRNGDFFI SSKDLGYDYS YLQDSDPDSF QDYIKSYLEQ ASRIWSWLLG AAMVGAVLTA LLAGLVSLLC RHKRKQLPEE KQPLLMEKED YHSLYQSHL
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