Monobenzone

Depigmenting Agent — DERMATOLOGICALS

Key facts

Monobenzone is an ofm drug in the Depigmenting Agent class catalogued in DrugCentral. It was first approved by the FDA in 1952. Its mechanism of action is classified as Melanin Synthesis Inhibitors. DrugCentral lists 6 molecular targets, including HDAC6, PTGS1 and PTGS2.

• Approval status: ofm (first approved 1952 by the FDA).
• Drug class: Depigmenting Agent.
• Mechanism of action: Melanin Synthesis Inhibitors.
• Molecular targets: HDAC6, PTGS1, PTGS2 and SLC6A2 (6 listed in DrugCentral).
• ATC code: D11AX13 (Other dermatologicals).
• Molecular formula: C13H12O2; molecular weight 200.24 g/mol.

Mechanism & targets

• Mechanism of action (MoA): Melanin Synthesis Inhibitors
• Established pharmacologic class: Depigmenting Agent

Molecular targets (6)

Target	Gene	Action	Activity
Histone deacetylase 6	HDAC6	unknown	IC50 6.00
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 5.99
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 5.43
Sodium-dependent noradrenaline transporter	SLC6A2	unknown	Ki 5.41
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 5.31
Tyrosinase	TYR	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1952-11-10	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
D11AX13	DERMATOLOGICALS › OTHER DERMATOLOGICAL PREPARATIONS › OTHER DERMATOLOGICAL PREPARATIONS › Other dermatologicals

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Monobenzone is on its molecule page.

• Molecular formula: C₁₃H₁₂O₂
• Molecular weight: 200.24 g/mol
• CAS number: —
• InChIKey: VYQNWZOUAUKGHI-UHFFFAOYSA-N
• PubChem CID: 7638

OC1=CC=C(OCC2=CC=CC=C2)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Monobenzone work?

Monobenzone is classified as Melanin Synthesis Inhibitors; its molecular targets in DrugCentral include HDAC6, PTGS1, PTGS2 and SLC6A2.

When was Monobenzone first approved?

Monobenzone was first approved by the FDA in 1952.

What drug class does Monobenzone belong to?

Monobenzone is in the Depigmenting Agent class.

What is the chemical formula of Monobenzone?

Monobenzone has the molecular formula C13H12O2 and a molecular weight of 200.24 g/mol.

Sources

• DrugCentral drug card 1834 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1388 — compound record and bioactivity
• PubChem CID 7638 — chemical identifiers
• DrugBank DB00600 — drug record
• FDA UNII 9L2KA76MG5 — substance identity
• DailyMed: FDA labels for Monobenzone — current prescribing information (label search)
• UniProt Q9UBN7 (HDAC6) — target protein
• UniProt P23219 (PTGS1) — target protein
• UniProt P35354 (PTGS2) — target protein
• UniProt P23975 (SLC6A2) — target protein
• UniProt P14679 (TYR) — target protein

How this page is built: methodology · editorial policy & corrections.