Betahistine

NERVOUS SYSTEM

Key facts

Betahistine is a drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including HRH3 and Hrh3. Recorded indications include Ménière's disease.

• Molecular targets: HRH3 and Hrh3 (2 listed in DrugCentral).
• Indications: Ménière's disease.
• ATC code: N07CA01 (Antivertigo preparations).
• Molecular formula: C8H12N2; molecular weight 136.20 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Ménière's disease

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Histamine H3 receptor	HRH3	inverse agonist	EC50 9.52
Histamine H3 receptor	Hrh3	unknown	Ki 5.69

ATC classification

ATC code	Therapeutic hierarchy
N07CA01	NERVOUS SYSTEM › OTHER NERVOUS SYSTEM DRUGS › ANTIVERTIGO PREPARATIONS › Antivertigo preparations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Hyponatraemia	158.4
Hypoglycaemia	154.1
Parkinsonism	145.4
Dizziness	134.6
Fall	123.2
Soft tissue mass	116.8
Oesophageal perforation	115.6
Peripheral circulatory failure	113.4
Dementia	112.8
Multiple drug therapy	109.1
Blood cholesterol decreased	109.0
Multimorbidity	108.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Betahistine is on its molecule page.

• Molecular formula: C₈H₁₂N₂
• Molecular weight: 136.20 g/mol
• CAS number: 5638-76-6
• InChIKey: UUQMNUMQCIQDMZ-UHFFFAOYSA-N
• PubChem CID: 2366

CNCCC1=CC=CC=N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Betahistine used for?

DrugCentral lists the following indications for Betahistine: Ménière's disease.

How does Betahistine work?

Its molecular targets in DrugCentral include HRH3 (inverse agonist) and Hrh3.

What is the chemical formula of Betahistine?

Betahistine has the molecular formula C8H12N2 and a molecular weight of 136.20 g/mol.

Sources

• DrugCentral drug card 346 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1446813 — compound record and bioactivity
• PubChem CID 2366 — chemical identifiers
• DrugBank DB06698 — drug record
• FDA UNII X32KK4201D — substance identity
• UniProt Q9Y5N1 (HRH3) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.