Histamine H3 receptor (HRH3)
Homo sapiens — UniProt Q9Y5N1
Data last refreshed: (UniProt release unknown)
Key facts
Histamine H3 receptor (HRH3) is a protein from Homo sapiens identified by UniProt accession Q9Y5N1, 445 residues long. MolForge cross-references it against 15 known binders and 226 disease associations.
- UniProt accession: Q9Y5N1; gene symbol HRH3.
- Organism: Homo sapiens.
- Length: 445 amino acids.
- Approved drugs acting on it (DrugCentral): Pitolisant and Betahistine.
- Top disease associations (Open Targets): narcolepsy-cataplexy syndrome, hypersomnia and Meniere disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histamine H3 receptor |
|---|---|
| UniProt accession | Q9Y5N1 |
| Gene | HRH3 |
| Organism | Homo sapiens |
| Length | 445 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (226)
Diseases linked to this target (Open Targets).
- narcolepsy-cataplexy syndrome · score 0.54
- hypersomnia · score 0.46
- Meniere disease · score 0.44
- neurodegenerative disease · score 0.37
- Vertigo · score 0.37
- restless legs syndrome · score 0.37
- narcolepsy · score 0.36
- Parkinson disease · score 0.33
- idiopathic hypersomnia · score 0.26
- glioblastoma multiforme · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5N1-F1 | alphafold | PREDICTED | 75.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5N1.
Amino-acid sequence (445 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target HRH3?
DrugCentral lists 2 approved drugs whose mechanism of action is HRH3: Pitolisant and Betahistine.
Which diseases are associated with HRH3?
The strongest Open Targets associations for HRH3 are narcolepsy-cataplexy syndrome, hypersomnia, Meniere disease, neurodegenerative disease and Vertigo.
How long is the HRH3 protein?
The Homo sapiens HRH3 protein (UniProt Q9Y5N1) is 445 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5N1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5N1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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