Canrenone

CARDIOVASCULAR SYSTEM

Key facts

Canrenone is a drug catalogued in DrugCentral. DrugCentral lists 1 molecular target, including NR3C2.

• Molecular targets: NR3C2 (1 listed in DrugCentral).
• ATC code: C03DA03 (Aldosterone antagonists).
• Molecular formula: C22H28O3; molecular weight 340.46 g/mol.

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Mineralocorticoid receptor	NR3C2	antagonist	IC50 6.52

ATC classification

ATC code	Therapeutic hierarchy
C03DA03	CARDIOVASCULAR SYSTEM › DIURETICS › ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS › Aldosterone antagonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Sopor	222.3
Hyperkalaemia	219.3
Drug interaction	210.1
Hyponatraemia	71.4
Acute kidney injury	68.7
Hypotension	64.2
Syncope	59.5
Anaemia	57.2
Melaena	54.1
Bradycardia	51.9
Varicella virus test positive	45.4
Asthenia	43.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Canrenone is on its molecule page.

• Molecular formula: C₂₂H₂₈O₃
• Molecular weight: 340.46 g/mol
• CAS number: —
• InChIKey: UJVLDDZCTMKXJK-WNHSNXHDSA-N
• PubChem CID: 13789

C[C@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@]21CCC(=O)O1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Canrenone work?

Its molecular targets in DrugCentral include NR3C2 (antagonist).

What is the chemical formula of Canrenone?

Canrenone has the molecular formula C22H28O3 and a molecular weight of 340.46 g/mol.

Sources

• DrugCentral drug card 478 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1463345 — compound record and bioactivity
• PubChem CID 13789 — chemical identifiers
• DrugBank DB12221 — drug record
• FDA UNII 78O20X9J0U — substance identity
• UniProt P08235 (NR3C2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.