Chlorpropamide

Sulfonylurea — ALIMENTARY TRACT AND METABOLISM

Key facts

Chlorpropamide is an ofm drug in the Sulfonylurea class catalogued in DrugCentral. It was first approved by the FDA in 1958. DrugCentral lists 2 molecular targets, including ABCC8|KCNJ11 and Slc22a6. Recorded indications include Diabetes mellitus type 2.

• Approval status: ofm (first approved 1958 by the FDA).
• Drug class: Sulfonylurea.
• Molecular targets: ABCC8|KCNJ11 and Slc22a6 (2 listed in DrugCentral).
• Indications: Diabetes mellitus type 2.
• ATC code: A10BB02 (Sulfonylureas).
• Molecular formula: C10H13ClN2O3S; molecular weight 276.74 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Diabetes mellitus type 2

Off-label uses (1)

• Diabetes insipidus

Contraindications (14)

• Asthenia
• Breastfeeding (mother)
• Disease of liver
• Fever greater than 100.4 Fahrenheit
• Glucose-6-phosphate dehydrogenase deficiency anemia
• Heart disease
• Hemolytic anemia
• Hepatic porphyria
• Hypoglycemic disorder
• Hypopituitarism
• Primary adrenocortical insufficiency
• Prolonged-Severe Nausea and Vomiting
• Surgical procedure
• Traumatic injury

Mechanism & targets

• Established pharmacologic class: Sulfonylurea

Molecular targets (2)

Target	Gene	Action	Activity
Sulfonylurea receptor 1, Kir6.2	ABCC8|KCNJ11	blocker	Kd 5.05
Solute carrier family 22 member 6	Slc22a6	unknown	Ki 4.40

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1958-10-28	FDA	—	PFIZER

ATC classification

ATC code	Therapeutic hierarchy
A10BB02	ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS › Sulfonylureas

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: G6PD · Actionable PGx

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Chlorpropamide is on its molecule page.

• Molecular formula: C₁₀H₁₃ClN₂O₃S
• Molecular weight: 276.74 g/mol
• CAS number: 94-20-2
• InChIKey: RKWGIWYCVPQPMF-UHFFFAOYSA-N
• PubChem CID: 2727

CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Chlorpropamide used for?

DrugCentral lists the following indications for Chlorpropamide: Diabetes mellitus type 2.

How does Chlorpropamide work?

Its molecular targets in DrugCentral include ABCC8|KCNJ11 (blocker) and Slc22a6.

When was Chlorpropamide first approved?

Chlorpropamide was first approved by the FDA in 1958.

What drug class does Chlorpropamide belong to?

Chlorpropamide is in the Sulfonylurea class.

What is the chemical formula of Chlorpropamide?

Chlorpropamide has the molecular formula C10H13ClN2O3S and a molecular weight of 276.74 g/mol.

Sources

• DrugCentral drug card 622 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL498 — compound record and bioactivity
• PubChem CID 2727 — chemical identifiers
• DrugBank DB00672 — drug record
• FDA UNII WTM2C3IL2X — substance identity
• DailyMed: FDA labels for Chlorpropamide — current prescribing information (label search)
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.