Tolbutamide

Sulfonylurea — ALIMENTARY TRACT AND METABOLISM

Key facts

Tolbutamide is an ofm drug in the Sulfonylurea class catalogued in DrugCentral. It was first approved by the FDA in 1961. DrugCentral lists 3 molecular targets, including ABCC8|KCNJ11, Kcnj11 and Slc22a6. Recorded indications include Diabetes mellitus type 2 and Diagnostic Test for Pancreatic Islet Cell Adenoma.

• Approval status: ofm (first approved 1961 by the FDA).
• Drug class: Sulfonylurea.
• Molecular targets: ABCC8|KCNJ11, Kcnj11 and Slc22a6 (3 listed in DrugCentral).
• Indications: Diabetes mellitus type 2 and Diagnostic Test for Pancreatic Islet Cell Adenoma.
• ATC code: A10BB03 (Sulfonylureas).
• Molecular formula: C12H18N2O3S; molecular weight 270.35 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Diabetes mellitus type 2
• Diagnostic Test for Pancreatic Islet Cell Adenoma

Contraindications (12)

• Alcoholism
• Asthenia
• Disease of liver
• Fever greater than 100.4 Fahrenheit
• Hepatic porphyria
• Hypoglycemic disorder
• Hypopituitarism
• Kidney disease
• Primary adrenocortical insufficiency
• Prolonged-Severe Nausea and Vomiting
• Surgical procedure
• Traumatic injury

Mechanism & targets

• Established pharmacologic class: Sulfonylurea

Molecular targets (3)

Target	Gene	Action	Activity
Sulfonylurea receptor 1, Kir6.2	ABCC8|KCNJ11	blocker	Kd 5.05
ATP-sensitive inward rectifier potassium channel 11	Kcnj11	blocker	IC50 4.50
Solute carrier family 22 member 6	Slc22a6	unknown	Ki 4.26

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1961-06-22	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A10BB03	ALIMENTARY TRACT AND METABOLISM › DRUGS USED IN DIABETES › BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS › Sulfonylureas
V04CA01	VARIOUS › DIAGNOSTIC AGENTS › OTHER DIAGNOSTIC AGENTS › Tests for diabetes

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: G6PD · Actionable PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Lip infection	60.6
Bronchitis viral	47.0
Infected bite	43.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Tolbutamide is on its molecule page.

• Molecular formula: C₁₂H₁₈N₂O₃S
• Molecular weight: 270.35 g/mol
• CAS number: 64-77-7
• InChIKey: JLRGJRBPOGGCBT-UHFFFAOYSA-N
• PubChem CID: 5505

CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tolbutamide used for?

DrugCentral lists the following indications for Tolbutamide: Diabetes mellitus type 2 and Diagnostic Test for Pancreatic Islet Cell Adenoma.

How does Tolbutamide work?

Its molecular targets in DrugCentral include ABCC8|KCNJ11 (blocker), Kcnj11 (blocker) and Slc22a6.

When was Tolbutamide first approved?

Tolbutamide was first approved by the FDA in 1961.

What drug class does Tolbutamide belong to?

Tolbutamide is in the Sulfonylurea class.

What is the chemical formula of Tolbutamide?

Tolbutamide has the molecular formula C12H18N2O3S and a molecular weight of 270.35 g/mol.

Sources

• DrugCentral drug card 2696 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200874 — compound record and bioactivity
• PubChem CID 5505 — chemical identifiers
• DrugBank DB01124 — drug record
• FDA UNII 982XCM1FOI — substance identity
• DailyMed: FDA labels for Tolbutamide — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.