Clemizole

Drug profile

Key facts

Clemizole is a drug catalogued in DrugCentral. DrugCentral lists 9 molecular targets, including HRH4, Trpc5 and TRPC5.

• Molecular targets: HRH4, Trpc5, TRPC5 and TRPC6 (9 listed in DrugCentral).
• Molecular formula: C19H20ClN3; molecular weight 325.84 g/mol.

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Histamine H4 receptor	HRH4	unknown	Ki 6.40
Short transient receptor potential channel 5	Trpc5	unknown	IC50 5.96
Short transient receptor potential channel 5	TRPC5	blocker	IC50 5.96
Short transient receptor potential channel 6	TRPC6	blocker	IC50 5.89
Heme oxygenase 2	Hmox2	unknown	IC50 5.47
Short transient receptor potential channel 4	TRPC4	blocker	IC50 5.19
Short transient receptor potential channel 4	Trpc4	unknown	IC50 5.19
Short transient receptor potential channel 3	TRPC3	blocker	IC50 5.04
Short transient receptor potential channel 7	Trpc7	unknown	IC50 4.58

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Clemizole is on its molecule page.

• Molecular formula: C₁₉H₂₀ClN₃
• Molecular weight: 325.84 g/mol
• CAS number: 442-52-4
• InChIKey: CJXAEXPPLWQRFR-UHFFFAOYSA-N
• PubChem CID: 2782

ClC1=CC=C(CN2C(CN3CCCC3)=NC3=C2C=CC=C3)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Clemizole work?

Its molecular targets in DrugCentral include HRH4, Trpc5, TRPC5 (blocker) and TRPC6 (blocker).

What is the chemical formula of Clemizole?

Clemizole has the molecular formula C19H20ClN3 and a molecular weight of 325.84 g/mol.

Sources

• DrugCentral drug card 672 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1407943 — compound record and bioactivity
• PubChem CID 2782 — chemical identifiers
• DrugBank DB15932 — drug record
• FDA UNII T97CB3796L — substance identity
• UniProt Q9H3N8 (HRH4) — target protein
• UniProt Q9UL62 (TRPC5) — target protein
• UniProt Q9Y210 (TRPC6) — target protein
• UniProt Q9UBN4 (TRPC4) — target protein
• UniProt Q13507 (TRPC3) — target protein

How this page is built: methodology · editorial policy & corrections.