Dextrothyroxine
CARDIOVASCULAR SYSTEM
Also known as: choloxin, D-Thyroxine, dextrothyroxine sodium, sodium dextrothyroxine
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Dextrothyroxine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1967. DrugCentral lists 3 molecular targets, including Thrb, Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a and THRA|THRB. Recorded indications include Hyperlipidemia.
- Approval status: ofm (first approved 1967 by the FDA).
- Molecular targets: Thrb, Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a and THRA|THRB (3 listed in DrugCentral).
- Indications: Hyperlipidemia.
- ATC code: C10AX01 (Other lipid modifying agents).
- Molecular formula: C15H11I4NO4; molecular weight 776.87 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Hyperlipidemia
Mechanism & targets
Molecular targets (3)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Thyroid hormone receptor beta | Thrb | unknown | IC50 7.46 |
| Glutamate NMDA receptor | Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a | unknown | IC50 6.48 |
| Thyroid hormone receptor | THRA|THRB | agonist | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1967-04-14 | FDA | — | ABBVIE |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
C10AX01 | CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, PLAIN › Other lipid modifying agents |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Dextrothyroxine is on its molecule page.
| Molecular formula | C15H11I4NO4 |
|---|---|
| Molecular weight | 776.87 g/mol |
| CAS number | 51-49-0 |
| InChIKey | XUIIKFGFIJCVMT-GFCCVEGCSA-N |
| PubChem CID | 8730 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Dextrothyroxine used for?
DrugCentral lists the following indications for Dextrothyroxine: Hyperlipidemia.
How does Dextrothyroxine work?
Its molecular targets in DrugCentral include Thrb, Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3b|Grin3a and THRA|THRB (agonist).
When was Dextrothyroxine first approved?
Dextrothyroxine was first approved by the FDA in 1967.
What is the chemical formula of Dextrothyroxine?
Dextrothyroxine has the molecular formula C15H11I4NO4 and a molecular weight of 776.87 g/mol.
Browse: all drugs starting with D · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 846 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL3545058 — compound record and bioactivity
- PubChem CID 8730 — chemical identifiers
- DrugBank DB00509 — drug record
- FDA UNII 4W9K63FION — substance identity
- DailyMed: FDA labels for Dextrothyroxine — current prescribing information (label search)
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