Difenoxin

Antidiarrheal — ALIMENTARY TRACT AND METABOLISM

Key facts

Difenoxin is an ofp drug in the Antidiarrheal class catalogued in DrugCentral. It was first approved by the FDA in 1978. DrugCentral lists 1 molecular target, including OPRM1. Recorded indications include Diarrhea.

• Approval status: ofp (first approved 1978 by the FDA).
• Drug class: Antidiarrheal.
• Molecular targets: OPRM1 (1 listed in DrugCentral).
• Indications: Diarrhea.
• ATC code: A07DA04 (Antipropulsives).
• Molecular formula: C28H28N2O2; molecular weight 424.54 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Diarrhea

Contraindications (39)

• Achalasia of esophagus
• Alcoholism
• Angle-closure glaucoma
• Atony of colon
• Autonomic dysreflexia
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bleeding
• Brain damage
• Chronic heart failure
• Chronic lung disease
• Complete trisomy 21 syndrome
• Dehydration
• Disease of liver
• Disorder of coronary artery
• Disturbance of salivary secretion
• Drowsy
• Drug AND/OR toxin-induced diarrhea
• Gastric ulcer
• Gastrointestinal obstruction
• Hiatal hernia
• Hypertensive disorder
• Hyperthyroidism
• Kidney disease
• Liver function tests abnormal
• Myasthenia gravis
• Myocardial dysfunction
• Paralytic ileus
• Peptic reflux disease
• Pseudomembranous enterocolitis
• + 9 more

Mechanism & targets

• Established pharmacologic class: Antidiarrheal

Molecular targets (1)

Target	Gene	Action	Activity
Mu-type opioid receptor	OPRM1	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1978-07-14	FDA	—	SEBELA IRELAND LTD

ATC classification

ATC code	Therapeutic hierarchy
A07DA04	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › ANTIPROPULSIVES › Antipropulsives

Chemical structure

• Molecular formula: C₂₈H₂₈N₂O₂
• Molecular weight: 424.54 g/mol
• CAS number: 28782-42-5
• InChIKey: UFIVBRCCIRTJTN-UHFFFAOYSA-N
• PubChem CID: 34328

OC(=O)C1(CCN(CCC(C#N)(C2=CC=CC=C2)C2=CC=CC=C2)CC1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Difenoxin used for?

DrugCentral lists the following indications for Difenoxin: Diarrhea.

How does Difenoxin work?

Its molecular targets in DrugCentral include OPRM1 (agonist).

When was Difenoxin first approved?

Difenoxin was first approved by the FDA in 1978.

What drug class does Difenoxin belong to?

Difenoxin is in the Antidiarrheal class.

What is the chemical formula of Difenoxin?

Difenoxin has the molecular formula C28H28N2O2 and a molecular weight of 424.54 g/mol.

Sources

• DrugCentral drug card 878 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200599 — compound record and bioactivity
• PubChem CID 34328 — chemical identifiers
• DrugBank DB01501 — drug record
• FDA UNII 3ZZ5BJ9F2Q — substance identity
• DailyMed: FDA labels for Difenoxin — current prescribing information (label search)
• UniProt P35372 (OPRM1) — target protein

How this page is built: methodology · editorial policy & corrections.