Digitoxin

CARDIOVASCULAR SYSTEM

Key facts

Digitoxin is an ofm drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including ATP1A1, ATP1A1|ATP1B1|ATP1A3|ATP1B2|ATP1A2|ATP1B3|FXYD2|ATP1A4 and ATP1A2.

• Approval status: ofm.
• Molecular targets: ATP1A1, ATP1A1|ATP1B1|ATP1A3|ATP1B2|ATP1A2|ATP1B3|FXYD2|ATP1A4, ATP1A2 and STAT3 (6 listed in DrugCentral).
• ATC code: C01AA04 (Digitalis glycosides).
• Molecular formula: C41H64O13; molecular weight 764.95 g/mol.

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Sodium/potassium-transporting ATPase subunit alpha-1	ATP1A1	unknown	IC50 8.10
Sodium/potassium-transporting ATPase	ATP1A1|ATP1B1|ATP1A3|ATP1B2|ATP1A2|ATP1B3|FXYD2|ATP1A4	unknown	IC50 8.10
Sodium/potassium-transporting ATPase subunit alpha-2	ATP1A2	unknown	IC50 6.65
Signal transducer and activator of transcription 3	STAT3	unknown	IC50 6.15
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 4.86
Sodium/potassium-transporting ATPase subunit alpha-1	ATP1A1	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	LILLY

ATC classification

ATC code	Therapeutic hierarchy
C01AA04	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC GLYCOSIDES › Digitalis glycosides

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
General physical health deterioration	398.9
Atrial fibrillation	327.1
Product prescribing error	286.7
Product monitoring error	277.4
Bradycardia	228.2
Haematochezia	197.6
Arrhythmia	162.5
Anaemia	151.7
Systemic infection	151.4
Dyspnoea	141.3
Therapeutic drug monitoring analysis not performed	136.9
Renal cyst haemorrhage	124.5

Chemical structure

• Molecular formula: C₄₁H₆₄O₁₃
• Molecular weight: 764.95 g/mol
• CAS number: —
• InChIKey: WDJUZGPOPHTGOT-XUDUSOBPSA-N
• PubChem CID: 441207

C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3CC[C@@]4(C)[C@H](CC[C@@H]5[C@@H]4CC[C@]4(C)[C@H](CC[C@]54O)C4=CC(=O)OC4)C3)O[C@@H]2C)O[C@@H]1C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Digitoxin work?

Its molecular targets in DrugCentral include ATP1A1, ATP1A1|ATP1B1|ATP1A3|ATP1B2|ATP1A2|ATP1B3|FXYD2|ATP1A4, ATP1A2 and STAT3.

What is the chemical formula of Digitoxin?

Digitoxin has the molecular formula C41H64O13 and a molecular weight of 764.95 g/mol.

Sources

• DrugCentral drug card 881 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL254219 — compound record and bioactivity
• PubChem CID 441207 — chemical identifiers
• DrugBank DB01396 — drug record
• FDA UNII E90NZP2L9U — substance identity
• DailyMed: FDA labels for Digitoxin — current prescribing information (label search)
• UniProt P40763 (STAT3) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt P05023 (ATP1A1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.