Doripenem

Penem Antibacterial — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Doripenem is an ofm drug in the Penem Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 2007. DrugCentral lists 1 molecular target, including mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB. Recorded indications include Abdominal abscess, Cholecystitis, Complicated appendicitis and Complicated Urinary Tract Infections.

• Approval status: ofm (first approved 2007 by the FDA).
• Drug class: Penem Antibacterial.
• Molecular targets: mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (1 listed in DrugCentral).
• Indications: Abdominal abscess, Cholecystitis, Complicated appendicitis, Complicated Urinary Tract Infections and Infectious disease of abdomen and others.
• ATC code: J01DH04 (Carbapenems).
• Molecular formula: C15H24N4O6S2; molecular weight 420.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (6)

• Abdominal abscess
• Cholecystitis
• Complicated appendicitis
• Complicated Urinary Tract Infections
• Infectious disease of abdomen
• Pyelonephritis

Contraindications (2)

• Impaired renal function disorder
• Pseudomembranous enterocolitis

Mechanism & targets

• Established pharmacologic class: Penem Antibacterial

Molecular targets (1)

Target	Gene	Action	Activity
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2007-10-12	FDA	—	SHIONOGI INC

ATC classification

ATC code	Therapeutic hierarchy
J01DH04	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Carbapenems

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Systemic candida	53.1

Chemical structure

• Molecular formula: C₁₅H₂₄N₄O₆S₂
• Molecular weight: 420.50 g/mol
• CAS number: 148016-81-3
• InChIKey: AVAACINZEOAHHE-VFZPANTDSA-N
• PubChem CID: 73303

C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)=C(N2C1=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Doripenem used for?

DrugCentral lists the following indications for Doripenem: Abdominal abscess, Cholecystitis, Complicated appendicitis, Complicated Urinary Tract Infections, Infectious disease of abdomen and Pyelonephritis.

How does Doripenem work?

Its molecular targets in DrugCentral include mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (inhibitor).

When was Doripenem first approved?

Doripenem was first approved by the FDA in 2007.

What drug class does Doripenem belong to?

Doripenem is in the Penem Antibacterial class.

What is the chemical formula of Doripenem?

Doripenem has the molecular formula C15H24N4O6S2 and a molecular weight of 420.50 g/mol.

Sources

• DrugCentral drug card 4149 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4303454 — compound record and bioactivity
• PubChem CID 73303 — chemical identifiers
• DrugBank DB06211 — drug record
• FDA UNII BHV525JOBH — substance identity
• DailyMed: FDA labels for Doripenem — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.