Vaborbactam

beta Lactamase Inhibitor — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Vaborbactam is an onp drug in the beta Lactamase Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 2017. Its mechanism of action is classified as beta Lactamase Inhibitors. DrugCentral lists 1 molecular target, including blaKPC-2. Recorded indications include Escherichia coli urinary tract infection and Urinary tract infection caused by Klebsiella.

• Approval status: onp (first approved 2017 by the FDA).
• Drug class: beta Lactamase Inhibitor.
• Mechanism of action: beta Lactamase Inhibitors.
• Molecular targets: blaKPC-2 (1 listed in DrugCentral).
• Indications: Escherichia coli urinary tract infection and Urinary tract infection caused by Klebsiella.
• ATC code: J01DH52 (Carbapenems).
• Molecular formula: C12H16BNO5S; molecular weight 297.14 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Escherichia coli urinary tract infection
• Urinary tract infection caused by Klebsiella

Mechanism & targets

• Mechanism of action (MoA): beta Lactamase Inhibitors
• Established pharmacologic class: beta Lactamase Inhibitor

Molecular targets (1)

Target	Gene	Action	Activity
Beta-lactamase	blaKPC-2	unknown	Ki 7.25

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2017-08-29	FDA	—	REMPEX PHARMS INC

ATC classification

ATC code	Therapeutic hierarchy
J01DH52	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Carbapenems

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Vaborbactam is on its molecule page.

• Molecular formula: C₁₂H₁₆BNO₅S
• Molecular weight: 297.14 g/mol
• CAS number: —
• InChIKey: IOOWNWLVCOUUEX-WPRPVWTQSA-N
• PubChem CID: 56649692

OB1O[C@H](CC(O)=O)CC[C@@H]1NC(=O)CC1=CC=CS1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Vaborbactam used for?

DrugCentral lists the following indications for Vaborbactam: Escherichia coli urinary tract infection and Urinary tract infection caused by Klebsiella.

How does Vaborbactam work?

Vaborbactam is classified as beta Lactamase Inhibitors; its molecular targets in DrugCentral include blaKPC-2.

When was Vaborbactam first approved?

Vaborbactam was first approved by the FDA in 2017.

What drug class does Vaborbactam belong to?

Vaborbactam is in the beta Lactamase Inhibitor class.

What is the chemical formula of Vaborbactam?

Vaborbactam has the molecular formula C12H16BNO5S and a molecular weight of 297.14 g/mol.

Sources

• DrugCentral drug card 5253 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3317857 — compound record and bioactivity
• PubChem CID 56649692 — chemical identifiers
• DrugBank DB12107 — drug record
• FDA UNII 1C75676F8V — substance identity
• DailyMed: FDA labels for Vaborbactam — current prescribing information (label search)

How this page is built: methodology · editorial policy & corrections.