Fostemsavir

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Fostemsavir is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2020. DrugCentral lists 3 molecular targets, including env, env and KCNH2. Recorded indications include Human immunodeficiency virus I infection.

• Approval status: onp (first approved 2020 by the FDA).
• Molecular targets: env, env and KCNH2 (3 listed in DrugCentral).
• Indications: Human immunodeficiency virus I infection.
• ATC code: J05AX29 (Other antivirals).
• Molecular formula: C25H26N7O8P; molecular weight 583.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Human immunodeficiency virus I infection

Contraindications (1)

• Drug induction of cytochrome p450 CYP3A enzyme

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	env	unknown	Kd 9.08
Envelope glycoprotein gp160	env	inhibitor	Kd 9.08
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 4.66

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2021-02-04	EMA	—	ViiV HEALTHCARE B.V.
2020-07-02	FDA	—	ViiV Healthcare Company

ATC classification

ATC code	Therapeutic hierarchy
J05AX29	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Other antivirals

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Virologic failure	195.1
Pathogen resistance	131.6
Viral mutation identified	111.4
Viral load increased	80.8
Blood HIV RNA increased	59.1

Chemical structure

• Molecular formula: C₂₅H₂₆N₇O₈P
• Molecular weight: 583.50 g/mol
• CAS number: 864953-29-7
• InChIKey: SWMDAPWAQQTBOG-UHFFFAOYSA-N
• PubChem CID: 11317439

CC1=NN(C=N1)C2=NC=C(C3=C2N(C=C3C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5)COP(=O)(O)O)OC

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Fostemsavir used for?

DrugCentral lists the following indications for Fostemsavir: Human immunodeficiency virus I infection.

How does Fostemsavir work?

Its molecular targets in DrugCentral include env, env (inhibitor) and KCNH2.

When was Fostemsavir first approved?

Fostemsavir was first approved by the FDA in 2020.

What is the chemical formula of Fostemsavir?

Fostemsavir has the molecular formula C25H26N7O8P and a molecular weight of 583.50 g/mol.

Sources

• DrugCentral drug card 5401 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3301594 — compound record and bioactivity
• PubChem CID 11317439 — chemical identifiers
• DrugBank DB11796 — drug record
• FDA UNII 97IQ273H4L — substance identity
• DailyMed: FDA labels for Fostemsavir — current prescribing information (label search)
• UniProt Q12809 (KCNH2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.