Lasofoxifene
GENITO URINARY SYSTEM AND SEX HORMONES
Also known as: CP-336,156, CP-336156, fablyn, lasofoxifene tartrate
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Lasofoxifene is a drug catalogued in DrugCentral. It was first approved by the EMA in 2009. DrugCentral lists 3 molecular targets, including ESR1, ESR2 and Esr1|Esr2. Recorded indications include Postmenopausal osteoporosis.
- Molecular targets: ESR1, ESR2 and Esr1|Esr2 (3 listed in DrugCentral).
- Indications: Postmenopausal osteoporosis.
- ATC code: G03XC03 (Selective estrogen receptor modulators).
- Molecular formula: C28H31NO2; molecular weight 413.56 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Postmenopausal osteoporosis
Mechanism & targets
Molecular targets (3)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Estrogen receptor | ESR1 | agonist | IC50 8.89 |
| Estrogen receptor beta | ESR2 | agonist | IC50 8.74 |
| Estrogen receptor | Esr1|Esr2 | unknown | IC50 7.95 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 2009-02-24 | EMA | — | Dr. Friedrich Eberth Arzneimittel GmbH |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
G03XC03 | GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › Selective estrogen receptor modulators |
Chemical structure
| Molecular formula | C28H31NO2 |
|---|---|
| Molecular weight | 413.56 g/mol |
| CAS number | 180916-16-9 |
| InChIKey | GXESHMAMLJKROZ-UHFFFAOYSA-N |
| PubChem CID | 216416 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Lasofoxifene used for?
DrugCentral lists the following indications for Lasofoxifene: Postmenopausal osteoporosis.
How does Lasofoxifene work?
Its molecular targets in DrugCentral include ESR1 (agonist), ESR2 (agonist) and Esr1|Esr2.
When was Lasofoxifene first approved?
Lasofoxifene was first approved by the EMA in 2009.
What is the chemical formula of Lasofoxifene?
Lasofoxifene has the molecular formula C28H31NO2 and a molecular weight of 413.56 g/mol.
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Sources
- DrugCentral drug card 4308 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL328190 — compound record and bioactivity
- PubChem CID 216416 — chemical identifiers
- DrugBank DB06202 — drug record
- FDA UNII 337G83N988 — substance identity
- UniProt P03372 (ESR1) — target protein
- UniProt Q92731 (ESR2) — target protein
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